mCLM: A Modular Chemical Language Model that Generates Functional and Makeable Molecules

ICLROral2026

Authors: Carl Edwards, Chi Han, Gawon Lee, Thao Nguyen, Sara Szymkuć, Chetan Kumar Prasad, Bowen Jin, Jiawei Han, Ying Diao, Ge Liu, Hao Peng, Bartosz Andrzej Grzybowski, Martin D. Burke, Heng Ji
Affiliation: Genentech
Venue: ICLR 2026
Track: Oral

TL;DR

We propose mCLM: a bilingual, modular Chemical-Language Model that understands both natural language descriptions of functions and molecular blocks; mCLM front-loads synthesizability while improving the functions of molecules in a principled manner.

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Topics

language model molecule

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